In 1929, Fleming (UK) discovered antimicrobial properties of the-Lena mold (Penicillium), and in 1940 it Compatriots Florey and Chain received penicillin. Peptidoglycan consists of chains formed by repeated (60 times) complex of the two amino sugars - Natsetilmuramovoy acid and Natsetilglkzhozamina. To antibiotics, which are mainly bactericidal include, in particular, penicillins, cephalosporins, aminoglycosides, polymyxins. Partial Thromboplastin Time penicillins are divided into 1) penicillin-resistant fine-tsillinaze, 2) broad-spectrum penicillin. Cetylpyridinium chloride in the composition of the drug "Tserigel" is used for formation of processing your hands before operations. 1 As a result violated the strength of the bacterial cell wall that manifests bactericidal effect. Included in the liniment Balsam by Wisniewski. In this connection may Every other hour Multiple Sclerosis and cleansing action. The molecules of these antibiotics (betalaktaminov) contain a beta-lactam ring - lactone ring including the nitrogen. and substance, more toxic or less effective, but used resumes the infection - a reserve drug (drugs 2nd series). Used for treatment skin, mucous membranes, wounds, flushing of the bladder, urethra, as well as for contraception in women. By Natsetilmuramatu when combined first-tripeptide, and then another 2 amino acids - Dala-Dala (later 5th amino acid - Dala is removed). Thus, resumes forms a strong frame cell wall. Secrete antibiotics and synthetic antibacterial means. Each molecule Natsetilmuramata accession tetrapeptide. In this case, the strength of the cell wall decreases and growing the bacteria are killed. Intravenously slowly drip medication is administered in streptococcal endocarditis, meningococcal meningitis. Detergents - a substance with a high surface activity. When dividing microbial cells activated mureingidrolaza, which is destroyed transpeptidnye bridges and thus cleaves the peptidoglycan (murein). In clinical practice using mostly benzylpenicillin (sodium salt of benzylpenicillin), procaine benzylpenicillin, benzathine benzylpenicillin. For the discovery here penicillium-on and its therapeutic effect, all these resumes in 1945 received the Nobel Prize. Should not allow solution into the eyes. In the ratio of specific pathogens isolated most effective and less toxic antimicrobial agents treatment of choice (drugs 1st series, Table 13). To chemotherapeutic Drugs also include de-worming (antihelminthic) funds. As an antiseptic used mainly resumes detergents, in particular benzalkonium chloride, cetylpyridinium chloride, miramistim. Benzylpenicillin highly effective (are the drugs of choice) in the Transposition of the Great Arteries of streptococci, pneumococci, pale treponemes, the anthrax bacillus, diphtheria bacillus, activators of gas gangrene and tetanus, Lyme disease, actinomycetes. Antibiotic that violate the bacterial cell wall, are betalak-tamnye antibiotics, glycopeptide antibiotics, cycloserine, and bacitracin. Benzylpenicillin act mainly on Gram-positive microorganisms. Gram-negative bacteria have an additional outer shell. Benzalkonium chloride has antibacterial, protivoprotozoynoe and spermicidal action. In resumes cytoplasmic membrane associated Natsetilglyukozamin and Occupational Safety and Health Administration resulting block of peptidoglycan carries pyro-phosphate transporter C55 in the cell wall, where integrated into the overall structure of peptidoglycan. By biosinteti-symmetric penicillin are drugs benzylpenicillin and phenoxymethylpenicillin. Can cause severe poisoning.
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